Simulation and Theory of Antibody Binding to Crowded Antigen-Covered Surfaces
Fig 1
The coarse-grained model of IgGs.
A) The two Fab domains are in red, while the Fc stem is shown in blue. The yellow transparent spheres picture attractive spherical domains (radial piece-wise potentials) that link together the three domains (in the hinge region) and allow binding an antigen (Fab tips). The T-shaped crystallographic structure 1IGY is also shown for comparison. B) Snapshot from our simulations, showing a close-up of the antigen-covered surface. Antigens are recognizable as pink spots on the surface.
