Modeling of the axon membrane skeleton structure and implications for its mechanical properties
Fig 1
(A) Illustration of the axon membrane skeleton based on super-resolution microscopy results [3] exhibiting actin rings connected by spectrin tetramers. Ankyrin associated Nav channels anchor the lipid bilayer to the membrane skeleton. Adducin has also been observed to colocalize with the actin rings possibly capping actin filaments. (B) A coarse-grain membrane skeleton dynamics model comprising representation of actin rings, spectrin filaments, and ankyrin. The insert shows the dimensions of the considered particles. (S2 Fig)
