Unraveling ChR2-driven stochastic Ca2+ dynamics in astrocytes: A call for new interventional paradigms
Fig 2
Response of ChR2 variants to light stimulation.
Representative traces (90 minutes in duration) of IP3 concentration ([IP3]), cytosolic calcium concentration ([Ca2+]c), fraction of open inactivation IP3R gates (h), and total calcium concentration ([Co]) for an astrocyte expressing various ChR2 variants (wild type 1 (WT1), wild type 2 (WT2), ChETA and ChRET/TC) in response to light stimulation (T = 2 s, δ = 20% (0.4 s), unit amplitude). The blue horizontal solid line indicates the stimulation window.
