High-Resolution Mapping Reveals Links of HP1 with Active and Inactive Chromatin Components
Figure 3
Preferential Binding of HP1 to Exon-Dense Genes
(A–C) Pie charts showing the overlap of GATC fragments with promoters (black), 5′ UTRs (green), exons (yellow), introns (white), 3′ UTR (black), and intergenic regions (blue) for all fragments represented on the high-density oligonucleotide array (top) and only those fragments that are significantly bound by HP1 (bottom). This analysis was performed for (A) all fragments, (B) nonpericentric fragments, and (C) pericentric fragments. (D and E) Density plot showing the frequency distribution of exon densities (i.e., the fraction of sequence in transcription units that consists of exons) for genes with high HP1 levels (red) and genes with low HP1 levels (black), in (D) nonpericentric and (E) pericentric genes. Only genes with a length >5 kb were included in this analysis.
