Elevated Expression of the Integrin-Associated Protein PINCH Suppresses the Defects of Drosophila melanogaster Muscle Hypercontraction Mutants
Figure 5
Moderately elevated expression of wild-type PINCH rescues the size and motility defects of flw7 mutants.
A) The lengths of four-day-old larvae were measured, normalizing to the mean of a parallel w1118 control. Mean±SEM for each genotype is shown, with the number of animals measured (n) shown above the bar on the graph. **** indicates p<0.0001 compared to the w1118 control. B) Representative phase contrast images of six L3 larvae of the indicated genotypes. Scale bar = 1 mm. C) The larval motility assay uses a 5 cm grape agar plate divided into zones as shown. D) The average percentage of larvae located in each zone at the end of the motility assay is plotted for the indicated genotypes, arranged in order of decreasing motility.
