Elevated Expression of the Integrin-Associated Protein PINCH Suppresses the Defects of Drosophila melanogaster Muscle Hypercontraction Mutants
Figure 7
Increased expression of PINCH-Flag rescues geotaxis defects and thoracic indentation, but does not reverse hypercontraction of the IFM in the Samba1 mutant.
A) For each genotype, a normalized geotaxis score from >5 independent assays is plotted as the mean±SEM. *** indicates p<0.001 and ns indicates p>0.05 when compared to the corresponding control data. B) Representative polarized light images of thoraces show that the IFM in the Samba1 mutant exhibits hypercontraction that is not rescued upon expression of PINCH-Flag. Asterisks indicate areas of hypercontraction within the structure of the IFM. C) A dorsal view shows that the thoracic indentations prevalent in Samba1/+ adults are rescued upon expression of transgenic PINCH-Flag. White arrowheads indicate the areas of indentation.
