NSAIDs Modulate Clonal Evolution in Barrett's Esophagus
Figure 6
BEAST analysis suggests that NSAID use reduces the SGA rate (number of SGA events per genome per year).
For all individuals (a–m), the mean off-NSAID SGA rate was 7.8 (95% support interval [SI]: 7.1–8.6) and the mean on-NSIAD SGA rate was 0.6 (95% SI: 0.3–1.5). For individuals a–k, the mean off-NSAID SGA rate was 8.8 (95% SI: 8.1–9.5,), whereas the mean on-NSAID SGA rate was 0.2 (95% SI: 0.03–1.0). For the two individuals l and m that started surveillance on NSAIDs and then went off NSAIDs, there are mixed results. The mean on-NSAID SGA rate for individual l was 3.1 (95% SI: 2.2–4.7) and the mean off-NSAID SGA rate was 4.4 (95% SI: 3.1–5.9). However, for individual m the mean on-NSAID SGA rate was 2.5 (95% SI: 2.1–3.0) and the mean off-NSAID SGA rate was 0.1 (95% SI: 0.01–0.6). Note that confidence intervals are tighter for the earlier time period for each individual as more inferred ancestry events fell within that time period.
