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RPM-1 Uses Both Ubiquitin Ligase and Phosphatase-Based Mechanisms to Regulate DLK-1 during Neuronal Development

Figure 9

Summary of RPM-1 signaling.

RPM-1 is a positive regulator of the GLO-4 pathway, and acts as part of a complex with FSN-1 that ubiquitinates and negatively regulates DLK-1. PPM-2 is also part of an RPM-1 protein complex and negatively regulates DLK-1 via dephosphorylation at S874.

Figure 9

doi: https://doi.org/10.1371/journal.pgen.1004297.g009