Next-Generation “-omics” Approaches Reveal a Massive Alteration of Host RNA Metabolism during Bacteriophage Infection of Pseudomonas aeruginosa
Fig 2
PAK_P3 takes over the host cell transcription over the course of infection.
Three independent biological replicates of RNA extracts were harvested from PAK_P3 infected cells at 0min, 3.5min and 13min post infection, as well as a single sample collected at 6.5min and all were subsequently sequenced. Plotting the percentage of reads mapping to the PAK_P3 genome (A) and to the host genome (B) over the course of infection shows that PAK_P3 progressively dominates the transcriptional environment of the cell with phage transcripts.
