Aberrant neuronal activity-induced signaling and gene expression in a mouse model of RASopathy
Fig 9
Analysis of DEGs in hippocampi of control and Ptpn11D61Y mice in the basal state and after the stimulation of neuronal activity.
(A) The heat maps show the expression levels of DEG transcripts for each analyzed dataset. Three biological replicates (columns) per condition are shown for all DEGs (rows). The color code in a logarithmic scale is given for the signal intensities of the DEGs and indicates a low (in blue) or high (red) expression. (B) The Venn diagram shows the number of DEGs in each dataset. The intersections indicate the number of genes regulated in two or more datasets. (C) The table shows the number of differentially expressed mRNAs and miRNAs as well as the direction of their regulation in each dataset. (D-F) Plots show the inter-dependency of the expressional regulations of the DEGs that are commonly regulated between the datasets. Each data point represents one DEG; the x- and y-axis indicate the level of regulation as fold change in a logarithmic scale in the dataset. The correlation coefficient (r) and p-value are indicated in the graphs. The black lines show the best fits; the dashed lines indicate the 95% confidence intervals.
