Aberrant neuronal activity-induced signaling and gene expression in a mouse model of RASopathy
Fig 10
The PI3K-AKT signaling is altered in Ptpn11D61Y brains.
(A) Representative Western blots of forebrain homogenate from control and Ptpn11D61Y mice. The phosphorylation level of AKT at the residues Thr308 and Ser473 are reduced, while the phosphorylation of S6K is increased. See S8 Fig for representative images of all proteins analyzed. (B) Quantification of the Western blots exemplified in A. Data is shown as mean ± SEM and normalized to the expression in controls (n = 3 animals per genotype, unpaired t-test; *p<0.05; **, p<0.01).
