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Identification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic Trypanosomatids

Fig 4

Inhibition plot of Leishmania infantum trypanothione synthetase (TryS) by paullones.

The data are presented as mean TryS activity (%) ± 2 S.D. (n = 4) as function of Log₁₀ concentration (nM) of compound adjusted to a four-parameter Boltzmann sigmoidal equation. Representative dose-response plot obtained for MOL2008 (IC₅₀ = 0.14 ± 0.03 μM; slope plot 0.38 ± 0.03) and for FS-554 (IC₅₀ = 0.32 ± 0.73 μM; slope plot 0.37 ± 0.03).

doi: https://doi.org/10.1371/journal.pntd.0004617.g004