Characterization of a dual-action adulticidal and larvicidal interfering RNA pesticide targeting the Shaker gene of multiple disease vector mosquitoes
Fig 4
Sh.463 yeast IRP induces A. aegypti larval death.
A. aegypti larval consumption of inactivated dried Sh.463 yeast IRP tablets induced significant larval mortality in laboratory (A) and outdoor semi-field (C) larvicide trials. In panels A and C, data are represented as mean percentage mortality; error bars represent SEM, and *** = P<0.001 in comparison to control yeast IRP-treated larvae. B. Consumption of inactivated dried Sh.463 yeast larvicide tablets induced larval mortality in the fourth instar (L4, days 4–6; compare to larvae fed with control yeast IRP that survived and pupariated). D. A dose-response curve depicting the dosage of Sh.463 yeast vs. the percentage mortality of A. aegypti larvae is shown; LD50 = 34 mg.
