Akt Deficiency Attenuates Muscle Size and Function but Not the Response to ActRIIB Inhibition

doi:10.1371/journal.pone.0012707

Akt Deficiency Attenuates Muscle Size and Function but Not the Response to ActRIIB Inhibition

Figure 1

Effects of ActRIIB inhibition on Akt levels in gastrocnemius muscle.

(A) Phosphorylated Akt (Ser473), total Akt1/2/3, and β-actin levels after 10 weeks of vehicle- (Veh) or ActRIIB-mFc treatment. (B) Total and p-Akt levels relative to β-actin. *p<0.05 vs. vehicle.

doi: https://doi.org/10.1371/journal.pone.0012707.g001

Akt Deficiency Attenuates Muscle Size and Function but Not the Response to ActRIIB Inhibition

Figure 1

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