Akt Deficiency Attenuates Muscle Size and Function but Not the Response to ActRIIB Inhibition
Figure 2
Effects of Akt deficiency and ActRIIB inhibition on body composition.
Effects of genotype and ActRIIB-mFc treatment (Rx, black bar) or vehicle (Veh, white bar) in wild-type (WT), Akt1 knockout mice (Akt1 KO), and Akt2 knockout mice (Akt2 KO) on (A) body weight, (B) percentage lean, (C) percentage fat. Data are mean +/− SEM, n = 5. + P<0.05 vs. WT treated with vehicle; ++ P<0.01 vs. WT treated with vehicle; *P<0.05 vs. same genotype treated with vehicle; **P<0.01 vs. same genotype treated vehicle.
