Akt Deficiency Attenuates Muscle Size and Function but Not the Response to ActRIIB Inhibition
Figure 3
Effects of Akt deficiency and ActRIIB inhibition on skeletal muscle weights.
Effects of genotype and ActRIIB-mFc treatment (Rx, black bar) or vehicle (Veh, white bar) in wild-type (WT), Akt1 knockout mice (Akt1 KO), and Akt2 knockout mice (Akt2 KO) on (A) Extensor digitorum longus, (B) Gastrocnemius (C) Quadriceps, (D) Tibialis Anterior, (E) Soleus, and (F) Heart. Data are mean +/− SEM, n = 5; + P<0.05 vs. WT treated with vehicle; ++ P<0.01 vs. WT treated with vehicle; +++P<0.0001 vs. WT treated with vehicle. *P<0.05 vs. same genotype treated with vehicle **P<0.01 vs. same genotype treated with vehicle; ***P<0.0001 vs. same genotype treated with vehicle.
