Akt Deficiency Attenuates Muscle Size and Function but Not the Response to ActRIIB Inhibition
Figure 6
Effects of Akt deficiency and ActRIIB inhibition on in vivo muscle function.
Effects of genotype (Veh, white bar) and ActRIIB-mFc treatment (Rx, black bar) in wild-type (WT), Akt1 knockout mice (Akt1 KO), and Akt2 knockout mice (Akt2 KO) on (A) forelimb grip strength; (B) distance ran during an endurance exercise protocol; (C) work done during an endurance protocol. Data is mean +/− SEM, n = 5; + P<0.05 vs. WT treated with vehicle; ++ P<0.01 vs. WT treated with vehicle. *P<0.05 vs. same genotype treated with vehicle.
