Akt Deficiency Attenuates Muscle Size and Function but Not the Response to ActRIIB Inhibition
Figure 7
Effects of Akt deficiency and ActRIIB inhibition on EDL contraction.
Effects of genotype (Veh, white bar) and ActRIIB-mFc treatment (Rx, black bar) on EDL ex vivo force generation. (A) Peak twitch force (mN) in wild-type (WT), Akt1 knockout mice (Akt1 KO), and Akt2 knockout mice (Akt2 KO); (B) Representative twitch recordings; (C) Peak tetanic force (mN). (D) Representative tetanic recordings. Data in (A, C) are mean +/− SEM, n = 5; + P<0.05 vs. WT treated with vehicle; ++ P<0.01 vs. WT treated with vehicle. *P<0.05 vs. same genotype treated with vehicle **P<0.01 vs. same genotype treated with vehicle.
