Akt Deficiency Attenuates Muscle Size and Function but Not the Response to ActRIIB Inhibition
Figure 8
Effects of ActRIIB inhibition on Akt signaling and glycogen content.
(A) Immunoblots of vehicle (Veh) and ActRIIB-mFc treated (Rx) wild-type (WT), Akt1 knockout (Akt1ko), and Akt2 knockout (Akt2ko) gastrocnemius lysates. P: phospho-specific antibody (B) Effects of genotype (Veh, white bar) and ActRIIB-mFc treatment (Rx, black bar) on quadriceps glycogen content (mg glycogen per g muscle). +++P<0.0001 vs. WT Veh, *p<0.05 vs. vehicle.
