HelmCoP: An Online Resource for Helminth Functional Genomics and Drug and Vaccine Targets Prioritization
Figure 3
Comparative genomics of ortholog group, ortho17taxa3159.
(A). Truncated output of the HelmCoP search (the complete search can be found in Table S4). Alignment of IUPRED (B) and RONN (C) disorder prediction programs. The disorder of the following proteins from ortho17taxa3159 were plotted: 14954.m01684 (B. malayi 1), 14954.m01756 (B. malayi 2), C42D85.a (C. elegans), CBG14607 (C. briggsae), CBN25768 (C. brenneri), CJA07982 (C. japonica), prot_Minc05651 (M. incognita 1), prot_Minc10796 (M. incognita 2), GENEPREDICTION_SNAP300000072512 (P. pacificus), Mh10g200708_Contig219_9296_12107 (M. hapla), CRE00266 (C. remanei). D. PDB entry 1UZE rendered using Pymol (Version 1.2r3pre) with helices, loops, and β-sheets colored red, yellow, and blue, respectively E. Alignment of the secondary-structure predictions downloaded from HelmCoP using JalView (Waterhouse et al. 2009). The sequences are colored based on clustalw (Thompson et al. 1994). For the secondary-structure prediction, helices are colored red, β-sheets blue, and random coils and loops are colored yellow. The disorder and secondary structure were aligned using in-house PERL script after aligning fasta sequences provided by HelmCoP using MUSCLE (Edgar 2004).
