Cerebellar Globular Cells Receive Monoaminergic Excitation and Monosynaptic Inhibition from Purkinje Cells
Figure 4
EPSCs recorded from cerebellar globular cells.
Globular cells were voltage-clamped at −70 mV in the presence of 20 µM SR95531 and 1 µM strychnine. (A) (upper traces) example of sEPSCs recorded from a globular cell. (lower traces) a nonselective ionotropic glutamate receptor antagonist, kynurenic acid, completely blocked sEPSCs. (B) Individual sEPSCs (20 gray traces) were aligned at their rise time and superimposed. The averaged trace is shown by a black curve. (C) EPSCs evoked by double shock granular layer stimulation with changing intervals (10, 20, 40, and 80 ms) are superposed. (D) Ratio of the second responses to the first ones is plotted as a function of the interpulse interval (n = 3−5).
