Identification and Validation of Ifit1 as an Important Innate Immune Bottleneck
Figure 1
Condensed networks of bottlenecks and functional clusters.
A network was inferred from the macrophage innate immune compendium (A), or the blood- (B) or brain-(C) derived transcriptome from the stroke study. Bottlenecks (circles) were identified based on topological betweenness and clusters (squares) were assessed for statistical enrichment in gene ontology functional categories versus genes in the rest of network using the hypergeometric test. Shared functions are indicated by cluster color: orange, immune related/stress response; pink, signaling; green, cell cycle/mitosis. Clusters are labeled with most enriched functional category followed by the negative exponent of the p-value for enrichment. Edges are colored red to indicate that the bottleneck is a member of the cluster that it links to, and red to indicate that the bottleneck is linked to the cluster. Note that not all bottlenecks, clusters or relationships between the two are present in this representation (see text).
