Effects of Exposure to a DNA Damaging Agent on the Hypoxia Inducible Factors in Organogenesis Stage Mouse Limbs
Figure 4
Localization of HIF2A immunoreactivity in limbs.
HIF-2A reactivity was detected in control limbs at 1 and 3 h in the apical ectodermal ridge, interdigital area (I.R.) and developing cartilaginous anlagen (Digits). 4-OOHCPA exposure increased HIF2A immunoreactivity in the apical ectodermal ridge and interdigital regions (I.R.) at 3 h. No differences were observed between control and drug-treated limbs after 6 h or 24 h of culture. Four separate replicates were done.
