Conditional Knockout of Integrin α2β1 in Murine Megakaryocytes Leads to Reduced Mean Platelet Volume
Figure 4
Platelet expression of integrins (A) α2β1 and (B) α5β1 determined by flow cytometry, using rat anti-mouse monoclonal antibodies.
The results are representative of four separate experiments. Platelets from the following mice were compared: (a) Pf4-Cre+;α2flox/flox; (b) Pf4-Cre+;α2flox/+; (c) Pf4-Cre(neg);α2flox/flox; and (d) C57BL/6 mice. As a negative control, (e) depicts the binding of an isotype identical, non-reactive IgG1 monoclonal antibody to platelets from Pf4-Cre+;α2flox/flox mice.
