Conditional Knockout of Integrin α2β1 in Murine Megakaryocytes Leads to Reduced Mean Platelet Volume
Figure 6
(A) In vitro platelet aggregation in response to soluble type I human collagen. Heparinized platelet-rich-plasma from f/f (black), f/− (gray) or −/− (white) mice was incubated with the indicated concentrations of soluble type I collagen. Results are expressed as the mean ± SD (n≥4). The asterisks (*) denote results that are significantly different (p<0.5) from those obtained for f/f mice. (B) In vivo tail bleeding time. Tail bleeding times (sec) are depicted for 6 individual mice in each group together with the mean for each group (− − −).
