Notch1 Is a 5-Fluorouracil Resistant and Poor Survival Marker in Human Esophagus Squamous Cell Carcinomas
Figure 3
Hypoxia induction of Notch1 and other stemness factors in vitro.
Notch1 is absent in the KYSE450 cells, but positive in KYSE70 cells under normoxia and even high level of Notch1 expression in these KYSE70 cells under hypoxia is shown. There are weak Hif-1α expression under normoxia and weak Hif-1α induction under hypoxia in KYSE450 cells. Comparably higher levels of expression and Hif-1α induction in KYSE70 cells are shown. Positivity and hypoxia induction of Hif-2α, Sox2, Oct3/4 and Hes-1 in KYSE450 cells and relatively stronger positivity and higher levels of hypoxia induction of these factors in KYSE70 cells are displayed.
