microRNA-122 Dependent Binding of Ago2 Protein to Hepatitis C Virus RNA Is Associated with Enhanced RNA Stability and Translation Stimulation
Figure 1
The HCV untranslated regions (UTRs), shown in the context of the HCV reporter RNA with the complete HCV 5′-UTR, partial core coding sequence (C), the firefly luciferase (Fluc) reporter gene and the HCV 3′-UTR with the variable region (VR), the poly(U/C)-tract (U/C) and the 3′-X region. The miR-122 seed target sites are shown as grey boxes, and the putative binding of miR-122 to the HCV 5′-terminal sequences is shown in the enlargement. The enlargement from the 3′-UTR shows the conserved ACACUCC sequence in the otherwise variable region.
