microRNA-122 Dependent Binding of Ago2 Protein to Hepatitis C Virus RNA Is Associated with Enhanced RNA Stability and Translation Stimulation
Figure 8
Hypothetical mechanism of the effect of miR-122 on HCV RNA stability and translation stimulation in cells.
The mature miR-122 guide strand is processed from its duplex precursor and incorporated into functional microRNA-protein (miRNP) complexes. These complexes target one or two miR-122 target sites (grey boxes) in the HCV 5′-UTR and confer HCV RNA stability and translation stimulation (indicated by the (+)).
