Nicotine Inhibits Memory CTL Programming
Figure 5
Nicotine effects on T-bet expression and mTOR signaling.
Sorted OT-I cells were stimulated with 3SI (antigen+B7+IL-12) in the presence of nicotine at different concentrations. Programmed CTLs were harvested at 3 days post-stimulation and analyzed for expression of T-bet, Eomes, S6, mTOR nad 4EBP. These are representatives of three independent experiments with similar results.
