Local Delivery of Polarized Macrophages Improves Reperfusion Recovery in a Mouse Hind Limb Ischemia Model
Figure 3
Effect of chlodronate liposomes on blood monocyte and granulocyte population (n=6).
Clodronate liposome treatment reduces the endogenous monocyte population significantly compared to PBS liposome treatment (***: p<0.001) and compared to single clodronate injection (#: p<0.05). A, Single injection with clodronate reduces the monocyte population with 53%, whereas a second injection results in 68% reduction. B, Granulocyte population increases upon clodronate treatment after double injections with clodronate compared to PBS-liposome treatment (***: p<0.001) and single clodronate injection (#: p<0.001), most probably due the depletion of the monocyte population.
