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Local Delivery of Polarized Macrophages Improves Reperfusion Recovery in a Mouse Hind Limb Ischemia Model

Figure 4

Reperfusion recovery after clodronate liposome treatment (n=9).

Reperfusion recovery is increased at day 14 in animals treated with either M1, M2a or M2c macrophages compared to NaCl treatment (***: p<0.001). Depletion of the circulating monocytes/macrophages did not inhibit reperfusion recovery and did not alter the effect of exogenously injected polarized macrophages.

Figure 4

doi: https://doi.org/10.1371/journal.pone.0068811.g004