Accessibility of Myofilament Cysteines and Effects on ATPase Depend on the Activation State during Exposure to Oxidants
Figure 2
Cysteines unique to an isoform are well conserved in vertebrate evolution.
A. Presence of unique cysteines in the rat isoforms, compared to their presence in human, rat chicken frog and zebrafish isoforms. Each row represents a cysteine that is found in only one of the isoforms of a rat myofilament protein. Columns represent species (evolutionary relationships are displayed at top). Red boxes indicate that the cysteine in the rat isoform is present in the isoform of the other species. B. Percent of histidine, cysteine, and methionine residues conserved across five vertebrate species (human, rat, chicken, frog, zebrafish) in fast and slow isoforms of TnI, TnC, RLC, and MLC. C. Percent of methionine, histidine and cysteine residues common to fast and slow isoforms of rat MHC, TnI, TnC, RLC and MLC relative to the total number in the fast isoform.
