Opposite Effect of Mast Cell Stabilizers Ketotifen and Tranilast on the Vasoconstrictor Response to Electrical Field Stimulation in Rat Mesenteric Artery
Figure 2
Vasoconstrictor response to EFS
(A) Isometric tension recording of the frequency-dependent contractions in intact mesenteric artery segments from Wistar rats. Effect of preincubation with 10 nmol ketotifen (B), 1 µmol/L ketotifen (C), 0.1 µmol/L ketotifen (D), 10 µmol/L tranilast (E), 0.1 mmol/L tranilast (F) or 1 mmol/L tranilast (G) for 1, 2 and 3 hours on frequency dependent contraction in mesenteric segments from Wistar rats. Results (means ± S.E.M.) are expressed as a percentage of tone induced by 75 mmol/L KCl. n= 10 animals each group.
