Opposite Effect of Mast Cell Stabilizers Ketotifen and Tranilast on the Vasoconstrictor Response to Electrical Field Stimulation in Rat Mesenteric Artery
Figure 3
Endothelium influence on vasoconstrictor response to EFS.
Effect of endothelium removal on the vasoconstrictor response to electrical field stimulation in control (A), ketotifen-incubated (B) or tranilast-incubated (C) mesenteric segments from Wistar rats. Results (means ± S.E.M.) are expressed as a percentage of tone induced by 75 mmol/L KCl. n= 10 animals each group. Insert graph shows differences of area under the curve (dAUC) in the absence or presence of 01 μmol/L phentolamine, expressed as arbitrary units. * P< 0.05 control vs. tranilast. (D) ACh-induced vasodilation in endothelium-intact control, ketotifen-incubated or tranilast-incubated mesenteric segments. Results (mean + S.E.M.) were expressed as a percentage of the previous tone elicited by exogenous NA. n = 6 animals each group.
