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Opposite Effect of Mast Cell Stabilizers Ketotifen and Tranilast on the Vasoconstrictor Response to Electrical Field Stimulation in Rat Mesenteric Artery

Figure 5

Effect of superoxide anions on NO-dependent vasodilation.

Effect of 0.1 mmol/L tempol on the concentration–response curves to DEA-NO in control (A) ketotifen-incubated (B) and tranilast-incubated (C) mesenteric segments.

Results (means + S.E.M.) are expressed as a percentage of the inhibition of the contraction induced by NA. n=6 animals each group.

Figure 5

doi: https://doi.org/10.1371/journal.pone.0073232.g005