Opposite Effect of Mast Cell Stabilizers Ketotifen and Tranilast on the Vasoconstrictor Response to Electrical Field Stimulation in Rat Mesenteric Artery
Figure 7
Effect of ketotifen or tranilast on sympathetic innervation function.
(A) Effect of preincubation with ketotifen or tranilast on the vasocostrictor response curves to noradrenaline. Effect of 0.1 µmol/L phentolamine on the frequency-response curve in control (B), ketotifen-incubated (C) or tranilast-incubated (D) segments. Results (means + S.E.M.) are expressed as a percentage of tone induced by 75 mmol/L KCl.
n = 5-6 animals each group. Insert graph shows differences of area under the curve (dAUC) in the absence or presence of 01 μmol/L phentolamine, expressed as arbitrary units. * P< 0.05 control vs. tranilast.
