Single Nucleotide Polymorphism Network: A Combinatorial Paradigm for Risk Prediction
Figure 5
Case and control specific genotypic fractions after single locus omission.
One SNP at a time is removed from all the genotypic set in the population to predict the probable risk genotype. The removed locus is denoted by * in the genotype supersets formed taking 4 loci at a time. The effect is studied in terms of the redistribution of number of unique genotypes (nodes) remaining after each SNP deletion in Case, Control and Common populations. The total number of genotype differs with different SNP combinations since once a particular SNP is removed; two genotypes may lose their variation and get collapsed to a single genotype.
