Bacterial Clearance Is Improved in Septic Mice by Platelet-Activating Factor-Acetylhydrolase (PAF-AH) Administration
Figure 3
Treatment with rPAF-AH increases MCP-1/CCL2 and NO levels in the peritoneal cavity after CLP.
Swiss mice were injected intraperitoneally with rPAF-AH (1 mg/kg) or vehicle 15 min after the CLP procedure (n = 6 in all groups). After 6 h, the peritoneal fluid was obtained and used for MCP-1/CCL2 (A) or NO (B) determination by ELISA and Griess assays, respectively. The values are the mean±SEM from 6 animals. (*) Statistically significant differences when compared to Sham group. (+) Statistically significant differences when compared to CLP+vehicle group.
