Bacterial Clearance Is Improved in Septic Mice by Platelet-Activating Factor-Acetylhydrolase (PAF-AH) Administration
Figure 4
CFU numbers are not affected by rPAF-AH treatment in MCP-1/CCR2-deficient mice (CCR2−/−) or iNOS-deficient mice (iNOS−/−) subjected to CLP. Mice were treated with rPAF-AH (1 mg/kg-i.p.
- minimum of 7 animals in each group) 15 min after CLP. At 6 h, the mice were euthanized, and the peritoneal fluid was plated on agar plates. The data represent three different experiments, and the horizontal line represents the median of CFU count. (*) Statistically significant differences when compared with C57BL-6 group. (+) Statistically significant differences when compared with C57BL-6+PAF-AH group.
