Pipoxolan Ameliorates Cerebral Ischemia via Inhibition of Neuronal Apoptosis and Intimal Hyperplasia through Attenuation of VSMC Migration and Modulation of Matrix Metalloproteinase-2/9 and Ras/MEK/ERK Signaling Pathways
Figure 2
Effects of PIPO on carotid-ligation induced intimal hyperplasia in mice.
Different doses of PIPO (10 and 30 mg/kg) was orally administered once a day for 28 days. (A) and (B) represent photomicrographs of hematoxylin-eosin staining, and (C) and (D) represents PCNA-immunoreactivity staining of arterial section (200 X). (E) I/M ratio. (F) Percentage of PCNA positive cells per total cells. The arrow was indicating the PCNA positive cell. Scale bar = 50 µm. *P< 0.05 and ***p< 0.001 compared with control group (n=5).
