Pipoxolan Ameliorates Cerebral Ischemia via Inhibition of Neuronal Apoptosis and Intimal Hyperplasia through Attenuation of VSMC Migration and Modulation of Matrix Metalloproteinase-2/9 and Ras/MEK/ERK Signaling Pathways
Figure 3
Effects of PIPO on PDGF-BB-induced VSMC migration by wound healing assay.
(A) A typical trace of PIPO (5, 10, and 15 µM) inhibited in response to PDGF-BB-induced VSMC migration. (B) Statistical differences in 24, 48 and 72 hr at different PIPO concentrations, respectively. Normal group was treated with vehicle. **P<0.01 and ***p<0.001 compared with PDGF-BB control group (n=6)..
