Pipoxolan Ameliorates Cerebral Ischemia via Inhibition of Neuronal Apoptosis and Intimal Hyperplasia through Attenuation of VSMC Migration and Modulation of Matrix Metalloproteinase-2/9 and Ras/MEK/ERK Signaling Pathways
Figure 4
Effects of PIPO on PDGF-BB-induced VSMC migration by transwell assay.
(A) Inhibition of PIPO (5, 10, and 15 µM) in response to PDGF-BB-induced VSMC migration. (B) Statistical differences of PIPO in response to PDGF-BB-induced VSMC migration at different PIPO concentrations. Normal group was treated with vehicle. **P <0.01 and ***p<0.001 compared with PDGF-BB control treated group (n=6)..
