Interleukin-6 Modulation of Intestinal Epithelial Tight Junction Permeability Is Mediated by JNK Pathway Activation of Claudin-2 Gene
Figure 12
Effect of siRNA induced knock-down of intestinal tissue AP-1 on IL-6 induced drop in intestinal tissue electrical resistance.
(A) siRNA induced knock-down of AP-1 in-vivo prevented the IL-6 induced increase in mouse intestinal claudin-2 protein expression as assessed by Western blot analysis. B) AP-1 siRNA transfection in-vivo prevented the IL-6 induced drop in mouse intestinal TER as measured in Ussing chambers (n = 5). *, p<0.001 vs. control; **, p<001 vs. IL-6 treatment.