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MiR-99a Antitumor Activity in Human Breast Cancer Cells through Targeting of mTOR Expression

Figure 4

Statistical correlation between the expression levels of miR-99a and mTOR protein in breast cancer tissues and cell lines (A) mTOR protein was analyzed by Western blotting in 10 pairs of breast cancer tissues.

(B) mTOR protein was analyzed in four different breast cancer cell lines and a breast epithelial cell line. Data were normalized to GAPDH protein and represent the mean ± SD of three independent duplicate experiments. *, P<0.05 significant differences from HBL-100. (C) The inverse correlation in breast cancer tissues was analyzed by Pearson's correlation method.

Figure 4

doi: https://doi.org/10.1371/journal.pone.0092099.g004