Relationship between Interleukin-6 Gene Polymorphism and Hippocampal Volume in Antipsychotic-Naïve Schizophrenia: Evidence for Differential Susceptibility?
Figure 6
Illustration of the differential susceptibility in contrast to diathesis-stress model.
Total hippocampal volume is represented against environmental adversity and polygenic liability that are known to be associated with schizophrenia (not quantified in this study). Pink and blue lines depict homozygous G and carrier of C rs1800795 genotypes respectively, that differ in their responsiveness to environmental and epistatic factors: the “plasticity” conferred by homozygous G is disproportionately more affected by influences compared to the “fixed” C carrier group. The gray line depicts “vulnerability”, that is affected only when exposed to an adversity, and this diathesis-stress view is not supported by data in the current study. In relation to these models, the bottom panel shows predicted probability of 'schizophrenia' outcome as the function of total hippocampal volume.
