Increased Cystic Fibrosis Transmembrane Conductance Regulators Expression and Decreased Epithelial Sodium Channel Alpha Subunits Expression in Early Abortion: Findings from a Mouse Model and Clinical Cases of Abortion
Figure 1
Findings for the CBA×DBA/2 abortion model.
(A) In the CBA×DBA/2 group (n = 11), 30 abortion-prone embryos were obtained, while in the control CBA×BALB/C group (n = 10), six abortion-prone embryos were obtained. (B) Implantation rates in the experimental group (8.18±2.14) and control group (7.90±1.79) (P>0.05). (C) Vaginal bleeding was observed on days 7–10 of pregnancy. (D) Representative image of abortion-prone and normal embryos: the arrows indicate the abortion-prone embryos with dysplasia appearance, in which fetuses and placentas can be hardly identified from each other. (E, F) Cross-sections of uterine tissue at the implantation site showed typical ischemia, hemorrhage, and necrosis in abortion-prone embryos (E), but not in healthy embryos (F) (scale bar: 300 µm). Green arrows indicate hemorrhage, and blue arrows indicate necrosis.
