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Effect of Natalizumab Treatment on Circulating Plasmacytoid Dendritic Cells: A Cross-Sectional Observational Study in Patients with Multiple Sclerosis

Figure 2

CD49d expression on plasmacytoid dendritic cells.

Mean fluorescence intensity (MFI) of CD49d on plasmacytoid dendritic cells (PDCs)(A) and frequency of PDCs expressing CD49d (B), in peripheral blood from untreated MS patients (UNT) and MS patients treated with natalizumab (NTZ) or interferon-β (IFN) determined by flow cytometry. Box-and-whisker plots showing mean, interquartile range, and min-max range. Representative histograms showing CD49d staining on PDCs from an UNT (blue open; C, E) and a NTZ-treated (red filled; D, E) patient.

Figure 2

doi: https://doi.org/10.1371/journal.pone.0103716.g002