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Effect of Natalizumab Treatment on Circulating Plasmacytoid Dendritic Cells: A Cross-Sectional Observational Study in Patients with Multiple Sclerosis

Figure 5

Effects of natalizumab treatment on plasmacytoid dendritic cells function.

Effects of natalizumab (NTZ) treatment on the functional ability of plasmacytoid dendritic cells (PDCs) to stimulate CD4 cell responses. PDCs were isolated from healthy controls using FACS sorting and stimulated with ODN-2006 for 18 hours in the presence of 15 µg/ml of NTZ or an isotype control and homologous CD4+ T cells were added. CD4+ T cells were isolated after an additional 6 days of incubation and cytokine mRNA expression determined using rt-PCR. Graph shows expression in cultures treated with NTZ or an isotype.

Figure 5

doi: https://doi.org/10.1371/journal.pone.0103716.g005