Genomic Analysis of Sleeping Beauty Transposon Integration in Human Somatic Cells
Figure 5
(A) Integration sites were annotated as “TSS-proximal” when occurring within a distance of ±2.5 kb from the gene's TSS, as “Intragenic” when occurring in a gene body and as “Intergenic” in all other cases. Black bars represent exons of a schematic gene, arrowhead indicates the direction of transcription. Distribution of SA, Tneo and random integration sites in the genome is plotted accordingly to defined annotations. (B) Distribution of Repetitive Elements in SB SA and Tneo libraries, in MLV and HIV libraries. Relative weighted random libraries were reported: TA and MseI-weighted for SA, TA-weighted for Tneo and MseI-weighted for MLV and HIV libraries. **p≤10−3, *p≤10−2.
