Monitoring Brain Tumor Vascular Heamodynamic following Anti-Angiogenic Therapy with Advanced Magnetic Resonance Imaging in Mice
Figure 1
HRI maps were obtained without (A, B, C, E, F, G) or with (I, J, K, M, N, O) constant air flow above the head. HRI maps are presented for both positive and negative pixels (A, I) and the corresponding SI time course (E, M); only for positive pixels (B, J) and the corresponding SI time course (F, N) and only for negative pixels (C, K) and the corresponding SI time course (G, O). In the graphs the time-curse (TC, red line) is calculated only for active pixels in the brain ROI (marked in blue on the HRI maps) and the ROI time-course (RTC, blue line) is the TC multiplied by the ratio of the number of active pixels divided by the total number of pixels in the ROI. It can be seen that when airflow is used the negative response is significantly lower and randomly distributed (K) compared to maps acquired without airflow (C). The corresponding T2W image is presented in (D) with the matching HRI superimposed on top (H). Note that the main blood vessels are clearly manifested on the HRI map. (L) The mean TC and RTC calculated from 44 HRI maps acquired with or without constant airflow are compared.
